DEMON: a Proposal for a Satellite-Borne Experiment to study Dark Matter and Dark Energy

We outline a novel satellite mission concept, DEMON, aimed at advancing our comprehension of both dark matter and dark energy, taking full advantage of two complementary methods: weak lensing and the statistics of galaxy clusters. We intend to carry out a 5000 sqdeg combined IR, optical and X-ray survey with galaxies up to a redshift of z~2 in order to determine the shear correlation function. We will also find ~100000 galaxy clusters, making it the largest survey of this type to date. The DEMON spacecraft will comprise one IR/optical and eight X-ray telescopes, coupled to multiple cameras operating at different frequency bands. To a great extent, the technology employed has already been partially tested on ongoing missions, therefore ensuring improved reliability.Comment: 12 pages, 3 figures, accepted for publication in the SPIE conference proceeding

On the evolution of the Gamma- and X-ray luminosities of Pulsar Wind Nebulae

Pulsar wind nebulae are a prominent class of very high energy (E > 0.1 TeV) Galactic sources. Their Gamma-ray spectra are interpreted as due to inverse Compton scattering of ultrarelativistic electrons on the ambient photons, whereas the X-ray spectra are due to synchrotron emission. We investigate the relation between the Gamma- and-X-ray emission and the pulsars' spin-down luminosity and characteristic age. We find that the distance-independent Gamma- to X-ray flux ratio of the nebulae is inversely proportional to the spin-down luminosity, (\propto \dot{E}^-1.9), while it appears proportional to the characteristic age, (\propto tau_c^2.2), of the parent pulsar. We interpret these results as due to the evolution of the electron energy distribution and the nebular dynamics, supporting the idea of so-called relic pulsar wind nebulae. These empirical relations provide a new tool to classify unidentified diffuse Gamma-ray sources and to estimate the spin-down luminosity and characteristic age of rotation powered pulsars with no detected pulsation from the X- and Gamma-ray properties of the associated pulsar wind nebulae. We apply these relations to predict the spin-down luminosity and characteristic age of four (so far unpulsing) candidate pulsars associated to wind nebulae.Comment: Accepted for publication in ApJ (6 pages, 2 figures

Test-Driven Design of an Active Dual-Polarized Log-Periodic Antenna for the Square Kilometre Array

An active dual-polarized Log-Periodic antenna has been designed to meet the requirements of the low-frequency (50-350 MHz) radio telescope of the Square Kilometre Array (SKA). The integration of antenna and low noise amplifier has been conceived in order to achieve a high degree of testability. This aspect has been found to be crucial to obtain a smooth frequency response compatible with the SKA science cases. The design has also been driven by other factors such as the large-volume production (more than 130 000 antennas will be built) and the environmental conditions of the harsh Australian desert. A specific verification approach based on both wideband radiometric spectral and spatial measurements in relevant laboratory and in-situ conditions has been developed. Electromagnetic analyses and experimental results exhibit a very good agreement. In December 2019, this antenna was part of the reference solution for the System Critical Design Review of the SKA

Giant inflammatory polyposis as the first manifestation of inflammatory bowel disease

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From MAD to SAD: the Italian experience for SKA-LFAA

The National Institute for Astrophysics (INAF) is deeply involved in the designing phase of the Low Frequency Aperture Array (LFAA) of the Square Kilometer Array (SKA). In particular, the technological contributions of INAF are basically spread in three main areas: (i) antenna and array pattern characterization and calibration, (ii) analog and photonic receiver design, and (iii) development of digital back-ends FPGA-based

From MAD to SAD: The Italian experience for the Low Frequency Aperture Array of SKA1-LOW

This paper describes two small aperture array demonstrators called Medicina and Sardinia Array Demonstrators (MAD and SAD, respectively). The objectives of these instruments are to acquire experience and test new technologies for a possible application to the low-frequency aperture array of the low-frequency telescope of the Square Kilometer Array phase 1 (SKA1-LOW). The MAD experience was concluded in 2014, and it turned out to be an important test bench for implementing calibration techniques based on an artificial source mounted in an aerial vehicle. SAD is based on 128 dual-polarized Vivaldi antennas and is 1 order of magnitude larger than MAD. The architecture and the station size of SAD, which is along the construction phase, are more similar to those under evaluation for SKA1-LOW, and therefore, SAD is expected to provide useful hints for SKA1-LOW

The UAV-based test source as an end-to-end verification tool for aperture arrays

A UAV-mounted radio-frequency transmitter is proposed as a known reference field source to perform a set of functional tests on aperture arrays. The experimental results obtained on complete prototypes (end-to-end) and sub-assemblies provide good confidence on both amplitude and timing verification

Metastatic Sites' Location and Impact on Patient Management After the Introduction of Prostate-specific Membrane Antigen Positron Emission Tomography in Newly Diagnosed and Biochemically Recurrent Prostate Cancer: A Critical Review

Context: The introduction of prostate-specific membrane antigen positron emission tomography (PSMA-PET) had a substantial impact on the management of prostate cancer (PCa) patients with a stage migration phenomenon and consequent treatment changes. Objective: To summarise the role of PSMA-PET to define the burden of disease through an accurate location of metastatic site(s) in PCa patients, describing the most common locations at PSMA-PET in the primary staging and recurrence setting, and to assess the clinical impact in the decision-making process. Evidence acquisition: A comprehensive nonsystematic literature review was performed in April 2022. Literature search was updated until March 2022. The most relevant studies have been summarised, giving priority to registered clinical trials and multicentre collaborations. Evidence synthesis: PSMA-PET showed higher diagnostic accuracy than conventional imaging both in newly diagnosed PCa and in recurrent disease. This greater accuracy led to a migration of a higher proportion of patients identified with metastatic disease. Bone metastases were reported as the most frequent site of metastatic spread in staging (up to 17%) and restaging (up to 18%). In staging, considering the suboptimal sensitivity in lymph node metastasis detection prior to radical surgery, PSMA-PET should be performed in patients with high risk or unfavourable intermediate risk only, and it is not recommended to routinely avoid pelvic lymph node dissection in case of a negative scan. In case of prostate-specific antigen relapse, PSMA-PET had higher diagnostic accuracy than other diagnostic procedures in the early detection of the sites of recurrence, thus influencing the therapy decision-making process. Conclusions: PSMA-PET detects a higher number of lesions than conventional imaging or other PET radiotracers, especially metastatic lesions unseen with other modalities. The high diagnostic accuracy of PSMA-PET leads to a significant patient upstage and thus an impact in clinical management, even if the overall impact on cancer mortality is still to be assessed. Patient summary: Prostate-specific membrane antigen positron emission tomography (PSMA-PET) identifies metastatic lesions with higher accuracy than conventional imaging, both in primary prostate cancer and during disease recurrence. Skeletal metastasis and extrapelvic lymph nodes are the most common sites of metastatic spread. The high accuracy of PSMA-PET in the detection of metastatic disease led to a significant impact on patient management, even if the overall impact on cancer mortality is still to be assessed